Molecular Formula: C15H24
CAS No: 515-13-9
β-Elemene (Beta-Elemene) CAS 515-13-9: High-Purity Biosynthetic Manufacturer
β-Elemene (CAS 515-13-9), also known as Beta-Elemene, is a high-value volatile sesquiterpene natural product. While traditionally extracted from ginger plants, HeshengTech has revolutionized its production using an advanced biosynthesis system in Saccharomyces cerevisiae. This sustainable method ensures high purity (≥98%) and a stable supply, overcoming the yield limitations of traditional plant extraction. Known for its distinctive tulip fragrance and potent anti-tumor properties, our β-Elemene meets the rigorous standards of the pharmaceutical and fragrance industries.
| Product Name | CAS Number | Molecular Formula | Purity | Application |
| β-elemene | C15H24 | 515-13-9 | / | Aromatherapy with fragrances/ Pharmaceutical Applications |
Tulip-Scented Anti-Tumor Natural Product
β-Elemene is a volatile sesquiterpene natural product, extracted and isolated from the traditional Chinese medicine ginger plant, characterized by a tulip fragrance.
This unique tulip scent gives β-Elemene a distinctive aroma, making it desirable as a unique spice.
Beyond its use as a spice, β-Elemene is recognized in China as an anti-tumor drug with independent intellectual property rights.
Significant Anti-Cancer Effects
Research indicates that β-Elemene exhibits strong anti-tumor activity, has a broad spectrum of action, can cross the blood-brain barrier, and exhibits minimal toxic side effects.
β-Elemene has been shown to potentially reverse the resistance of other anti-cancer drugs.
As a primary anti-cancer agent, β-Elemene demonstrates significant inhibitory effects on various cancer cells, including liver, lung, brain tumors, nasopharyngeal, esophageal, gastric, cervical, ovarian, leukemia, breast, bladder cancers, and bone metastases.
Industrial Production Challenges
Studies on the synthesis of β-Elemene in China are relatively scarce.
The low natural yield of β-Elemene struggles to meet market demands, and plant-extracted Elemene typically includes a mixture of β, γ, δ-Elemene.
Chemical synthesis allows for the isolated production of β-Elemene, but this method's use of highly toxic substances like sodium cyanide limits its commercial viability.
Hesheng Technology's Efficient β-Elemene Synthesis System
Hesheng Technology has developed an efficient synthesis system for β-Elemene within Saccharomyces cerevisiae.
The company employs high-throughput automation technology to screen for the synthase of Gemmarene A, a precursor in the synthesis of β-Elemene.
Following this, β-Elemene is obtained through a simple in vitro rearrangement process, enhancing the efficiency of its production.
Aromatherapy with fragrances
Pharmaceutical Applications
The Problem: Traditional plant extraction leads to low yields and a mixture of β, γ, and δ isomers, which are difficult to separate. Chemical synthesis often involves toxic precursors like sodium cyanide.
Hesheng's Innovation: Using High-Throughput Automation, we screened for the most efficient Germacrene A synthase. By rearranging this precursor in vitro, we achieve high-purity β-Elemene without toxic chemicals, providing an eco-friendly and scalable solution for global markets.
Beta-Elemene is widely recognized for its dual functionality. In the fragrance industry, it is valued for its unique tulip-like aroma. In the pharmaceutical sector, it is a potent anti-tumor agent known for its ability to cross the blood-brain barrier and inhibit various cancer cells, including lung, liver, and brain tumors.
Unlike plant-derived elemene which is a mixture of isomers, our biosynthetic β-elemene is produced via a targeted fermentation process. This allows us to isolate the beta-isomer more effectively, reaching a purity of over 98%, which is essential for pharmaceutical research and high-end aromatherapy.
Yes, when produced via our synthetic biology platform. By using Saccharomyces cerevisiae (yeast) as a cell factory, we eliminate the need for large-scale land use for ginger cultivation and avoid the harsh chemical solvents used in traditional synthesis, making it a "green" ingredient.
At Hesheng Technology, we specialize in synthetic biology and innovative natural product manufacturing. We offer advanced raw material solutions and welcome collaboration opportunities!
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